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Fig. 2. Effect of AREG and EGFR deficiency on postnatal mammary development. (A)
Carmine-stained whole mounts of paired wild-type,
Areg–/– (upper left and lower right panels)
and recombined mammary transplants grown for 3 weeks in the presence of
estradiol pellets. Scale bar: 1 mm. (B) Epithelial areas of 3-week-old,
estradiol-stimulated transplants with the indicated epithelial and stromal
genotypes (A–/–,
Areg–/–; WT, wild type). Lines connect paired
contralateral transplants from individual host mice and single data points
represent unpaired transplants. (C) Whole mounts of wild-type,
Egfr–/– and recombined 3-week-old transplants.
Scale bar: 1 mm. (D) Epithelial areas of 3-week-old transplants with the
indicated epithelial and stromal genotypes (R–/–,
Egfr–/–). (E) Histological appearance of
paired transplants. Similar alveolar morphologies and accumulation of luminal
secretory products (arrowheads) were seen in paired transplants from
individual hosts, regardless of the transplant genotype. Scale bar: 50
µm.
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