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Fig. 6. Elevating JNK signaling while blocking apoptosis promotes ectopic overgrowth of imaginal tissues. Adult wings (A-G). Foreleg (H). (A) Wild type, (B) en-Gal4/UAS-p35, (C-H) en-Gal4/UAS-p35;puc^A251.1/+. (E,F) Higher magnification of the overgrowths from C,D, respectively. Overgrowths occur only in the posterior compartment. Cells adopt appropriate fates. (G) Additional wing defects (disruption of polarity, extra wing vein material). (I-L) en-Gal4/UAS-p35;puc^A251.1/+. (I) DNA. (J,L) JNK^REP (red) and DNA (blue). (J) TUNEL label (green). Ectopic JNK^REP activity is associated with regions of overgrowth. (J) Less severe example. (L) More severe example. (K) Higher magnification of J. (M,N) Irradiated en-Gal4/UAS-p35;puc^A251.1/+. (M) JNK^REP (red) and DNA (blue). p35 does not inhibit JNK^REP activation in the posterior compartment. (N) DNA (blue). TUNEL label (green). p35 blocks radiation-induced apoptosis. (O,P) JNK^REP (red), Wg (green) and DNA (blue). (O) puc^A251.1/+ control. Normal pattern of Wg. (P) en-Gal4/UAS-p35;puc^A251.1/+. Wg is ectopically expressed by a subset of cells that activate the JNK^REP (arrowheads). (Inset) Higher magnification of P.

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