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Fig. 7. Fgf8-mediated promotion of lateral fast myogenesis in the zebrafish somite.
Schematic representation of muscle differentiation in wild-type (upper) and
Fgf8 loss-of-function (lower) 20 s embryos. Presomitic mesoderm expresses
myf5 (blue) in response to Fgf8 (green) diffusing from tailbud
(left). Fgf8 within the somite drives myod expression (red) in the
lateral posterior stripe of immature caudal somites (middle) and is required
for the later terminal differentiation of a full complement of fast muscle
fibres (red cylinders) in maturing rostral somites (right). Hedgehog proteins
from notochord (purple) induce myf5 and myod expression in
adaxial cells, leading to slow muscle differentiation (yellow) and subsequent
translation towards the lateral somite surface. In the absence of Fgf8,
expression of myod in lateral somite is reduced and less fast muscle
differentiates.
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