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Fig. 6. The entire striatum is severely compromised in Foxg1Cre; Notch1 conditional; Notch3 null double mutants (Foxg1Cre; N1; N3 DKOs). As visualized using in situ hybridization for Ebf1 in E17.5 coronal sections of the striatum, only a small region of the matrix compartment develops in the absence of both Notch1 and Notch3. Scale bar: 500 µm (upper right panel). Similarly, both the SCS and patch regions, immunostained here with antibodies to Darpp32, are substantially reduced in size and are severely disorganized in the double knockouts at E17.5. Scale bar: 500 µm. As seen in the lower panels, which show a higher magnification view than the middle panels, the SCS is disrupted and no characteristic clusters of Darpp32-positive cells are observed in Foxg1Cre; N1; N3 DKOs. Scale bar: 250 µm.

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