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Fig. 7. TGF ${alpha}$ functions equally and synergistically with HB-EGF in eyelid closure. (A,B) BrdU incorporation in eyelids of Tgfa^+/- (A) and Tgfa^-/- (B) E15.5 embryos. Scale bar: 100 µm for A,B. (C) Scoring of BrdU-positive cells shown in A and B. Data represent the mean value±s.e.m. of the results obtained from three individual embryos. N.S, not significant. (D) Progression of total eyelid formation (left panel), leading edge formation (middle panel) and root formation (right panel) in Tgfa^+/- (blue dots, n=14) and Tgfa^-/- (orange dots, n=12) eyelids. Horizontal bar in the graphs indicates the mean value. (E-G) TGF ${alpha}$ functions synergistically with HB-EGF in eyelid closure. Neonatal eyelid of wild-type animal (E) and double homozygote lacking both HB-EGF and TGF ${alpha}$ with an EOB phenotype (F). (G) Penetrance of EOB phenotype in compound mutants carrying HB-EGF null and TGF ${alpha}$ null alleles. Blue bars indicate pups with normal closed eyes; red bars indicate pups with EOB.

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