spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online December 28, 2004

Development 132, 202e (2005)
© The Company of Biologists Limited
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in Development
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content

In this issue

Neural induction controversy resolved?

Go


How neural induction is achieved in vertebrates is hotly debated. The default model of neural induction, which is based on experiments in frog ectodermal explants, proposes that inhibition of bone morphogenetic protein (BMP) signalling specifies neural fate. In chick and zebrafish embryos, however, neural induction is initiated by fibroblast growth factor (FGF) signalling. Delaune and colleagues now report that neural induction in whole frog embryos requires both FGF signalling and BMP inhibition (see p. 299). By using BMP and FGF signalling inhibitors, the researchers show that pre-gastrula ectodermal FGF signalling is required for neural induction in frogs. They propose that, in addition to inhibiting BMP, FGF signalling directly drives neural induction. However, definitive proof of a BMP-independent role for FGF signalling in frog neural induction awaits the identification of a transcriptional target that acts in a pathway that is essentially required for neural specification.


Related articles in Development:

Neural induction in Xenopus requires early FGF signalling in addition to BMP inhibition
Emilie Delaune, Patrick Lemaire, and Laurent Kodjabachian
Development 2005 132: 299-310. [Abstract] [Full Text]  




This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in Development
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content