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First published online September 28, 2005

Development 132, 2003e (2005)
© The Company of Biologists Limited
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In this issue

Chromatin remodellers: out on a limb


By controlling the access of transcription factors to individual genes, chromatin remodelling complexes help to regulate transcription. SWI2/SNF2 complexes contain one of two ATPases: brahma (BRM) or brahma-related gene 1 (BRG1). By using temporally controlled somatic mutagenesis during mouse embryogenesis, Indra and co-workers report on p. 4533 that BRG1 has distinct functions in limb morphogenesis and in the final stages of skin formation. By selectively ablating Brg1 in embryonic surface ectoderm and fetal epidermal keratinocytes, the researchers show that ectodermal BRG1 expression is required for hindlimb morphogenesis–its absence reduces FGF8 expression, which is needed to maintain the apical ectodermal ridge. Epidermal BRG1 expression is also required during keratinocyte terminal differentiation but BRM can partly substitute for BRG1 here; neither protein is essential for keratinocyte proliferation or early differentiation. These results begin to identify the developmental functions of BRG1 and BRM.


Related articles in Development:

Temporally controlled targeted somatic mutagenesis in embryonic surface ectoderm and fetal epidermal keratinocytes unveils two distinct developmental functions of BRG1 in limb morphogenesis and skin barrier formation
Arup Kumar Indra, Valérie Dupé, Jean-Marc Bornert, Nadia Messaddeq, Moshe Yaniv, Manuel Mark, Pierre Chambon, and Daniel Metzger
Development 2005 132: 4533-4544. [Abstract] [Full Text]  




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