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Fig. 4. Dishevelled-dependent PCP signaling governs cell polarity. (A) A schematic
of planar polarity establishment in the Drosophila wing (a higher
magnification view is shown in B). Dishevelled-dependent PCP signaling
coordinates the orientation of distally pointing, actin-rich hairs in these
cells. The arrangement of these cells remains constant, and long-term
cross-talk between neighboring cells is essential for polarity establishment.
(C) A schematic of planar polarity during convergent extension in
Xenopus (a higher magnification view is shown in D). Convergent
extension is driven by polarized cell interdigitation. By crawling between one
another along a single axis, the population of cells is converted from being
short and wide to long and narrow. Dishevelled-dependent PCP signaling is
essential to the stabilization of lamellipodia specifically on the
mediolateral faces of these cells. Unlike Drosophila wing cells,
these cells are constantly changing neighbours. How the PCP signaling cascade
has changed to accommodate this dynamic situation is a topic of great
interest. (E) Wing hairs on a normal Drosophila embryo all point
distally, but such polarity is perturbed in an embryo with disrupted
Dishevelled signaling (images courtesy of Jeff Axelrod, Stanford University
School of Medicine). (F) Xenopus mesoderm cells engaged in convergent
extension are aligned and polarized, but this polarity is perturbed in an
embryo with disrupted Dishevelled signaling.
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