Regulation of ocular lens development by Smad-interacting protein 1 involving Foxe3 activation
Development Yoshimoto et al.
132: 4437
DEV02022 Supplementary Material
Files in this Data Supplement:
Supplemental Figure 1
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Fig. S1. Effect
of exogenous Smads on SIP1-dependent activation of Foxe3 promoter in tranfected gizzard cells. As in lens cells (Fig. 6D), any
of the Smads, alone, has no effect on promoter activity, as exemplified by
Smad8. Of the eight Smads examined, only Smad8 augmented SIP1-dependent
activation level. This effect was absent when SIP1 lacked SBD.
Supplemental Figure 2
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Fig. S2. Comparison
of linker sequence between MH1 and MH2, in Smad8, Smad1 and Smad5.
