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Fig. 1. Sip1 expression in early lens development. Distribution of
Sip1 transcript detected by in situ hybridization of frontal sections
through eye. Dorsal side is towards the right. (A) At E9.0 before lens
induction, surface ectoderm does not express a significant level of
Sip1. (B) At E9.5 soon after lens induction, Sip1 expression
initiates in the lens placode. (C) At E10.5 in ectoderm derivatives,
Sip1 expression is maintained only in invaginating lens cells but not
in the adjacent surface ectoderm (future cornea). (D) At E11.5, all cells in
the lens vesicle show Sip1 expression. (E) At E13.5, once mature lens
fibers differentiate, they loose Sip1 expression, while immature lens
fibers in the bow region and the lens epithelium show strong Sip1
expression. (F) Section of E10.5 embryo hybridized with sense control probe.
se, surface ectoderm; ov, optic vesicle; lp, lens placode; lv, lens vesicle;
le, lens epithelium; lf, mature lens fibers. Bow regions are encircled by
broken lines. Scale bars: 100 µm.
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