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Fig. 5. Loss of Foxe3 expression in the epithelial compartment of
Sip1-defective lenses. (A-D) Normal lenses, (E-G)
Sip1-defective lenses and (H) dyl (Foxe3-defective)
mutant lens. Foxe3 is expressed strongly in the anterior compartment
(indicated by the broken line) of the lens vesicle that later contributes to
lens epithelium (A). In Sip1-defective lens, however, Foxe3
expression in the corresponding anterior compartment is missing (E) (a section
adjacent to Fig. 3F).
Accordingly, Pdgfra downstream of Foxe3
(Blixt et al., 2000) (B) is
attenuated in the corresponding compartment of the Sip1-defective
lens (F). However, Pax6, which is known to be involved in activation
of Foxe3 (Brownell et al.,
2000), is expressed at similar levels in normal (C) and
Sip1-defective lenses (G). Expression of Sip1 in normal lens
(D) is maintained in dyl (Foxe3) homozygous lenses (H).
Scale bars: 100 µm.
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