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First published online October 28, 2005

Development 132, 2202e (2005)
© The Company of Biologists Limited
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In this issue

HSPGs get specific

Heparan sulphate proteoglycans (HSPGs) are complex molecules that are critically important for signalling by secreted molecules during development. Despite this, pinning down their individual roles in development has proved a challenge. Norton and colleagues now report that the exostosins Ext2 and Extl3, which synthesise the HS sidechains of HSPG, are required for Fgf signalling during zebrafish development (see p. 4963). The researchers show that fgf10 is disrupted in deadalus, a zebrafish pectoral fin mutant that closely resembles ext2 and extl3 mutants. They report that while Fgf10 rescues target gene expression in fgf10 mutants, it does not do so in ext2 or extl3 mutants, indicating that HSPG synthesis is needed for Fgf10 signalling. The rescue of ext2 and extl3 mutants by Fgf4 revealed an unexpected specificity of HSPGs in regulating vertebrate Fgfs. On p. 5055, Stickens et al. report that Ext2-null mouse embryos fail to gastrulate, while Ext2+/– mice develop ectopic bony growths, providing further insights into Ext2's role in vertebrate development.


Related articles in Development:

HSPG synthesis by zebrafish Ext2 and Extl3 is required for Fgf10 signalling during limb development
William H. J. Norton, Johan Ledin, Heiner Grandel, and Carl J. Neumann
Development 2005 132: 4963-4973. [Abstract] [Full Text]  

Mice deficient in Ext2 lack heparan sulfate and develop exostoses
Dominique Stickens, Beverly M. Zak, Nathalie Rougier, Jeffrey D. Esko, and Zena Werb
Development 2005 132: 5055-5068. [Abstract] [Full Text]  




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