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Fig. 2. Defective DTC migration in the src-1(cj293) mutant. The position
of DTC was monitored by analyzing the expression of lag-2::gfp in
wild-type (A,C,E,G) and src-1(cj293) mutant (B,D,F,H) worms. The DTCs
migrate in opposite directions along the ventral body wall muscle during the
L2 stage in both the wild-type and mutant (A,B). However, the DTCs fail to
turn dorsally in the src-1(cj293) mutant (D) during the L3 stage and
continue their centrifugal migration in the anterior and posterior directions
(F). By contrast, in the wild-type worm at the adult stage, the DTCs migrate
centripetally along the dorsal muscle bands back toward the midbody (E). In
the adult src-1(cj293) mutant, the extended gonads are randomly bent
and accordionated (H). The arrowheads indicate the DTCs. Arrows show the
migration pattern of the DTCs. Scale bar: 100 µm.
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