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Fig. 7. Repression by the unliganded ecdysone receptor is lifted at different steps
in neurogenesis for different sets of SOPs. For the chemosensory neurons of
the margin we speculate that BR-Z2 activates SENS whereas BR-Z1 is required
for the accumulation of SENS in the mature SOP. BR-Z1 is repressed by the
unliganded EcR/USP complex. The control of br-Z2 expression has not
been established. The early born SOPs accumulate SENS prior to the rise of 20E
and are independent of BR function. EcR/USP repression inhibits the division
of the SOP. The rise in 20E relieves repression and allows the SOP to divide.
Grey represents low levels of SENS protein [adapted from Jafar-Nejad et al.
(Jafar-Nejad et al., 2003)];
black shows the mature SOPs that have accumulated SENS. Open arrow marks the
rise in 20E.