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Fig. 1. Six2 is upregulated in the second branchial arch of
Hoxa2-/- embryos. Whole-mount in-situ hybridization of
wild-type (A-C) and Hoxa2-/- (D-F) embryos. (A,D) E10.5
embryos. Six2 is detected in the Hoxa2 mutant second arch
(arrow) in a symmetrical location to its first arch counterpart. (B,E) E11.5
embryos. A small area expressing Six2 is visible in the wild-type
second arch (arrowhead). The mutant second arch is equivalent to the first
arch in terms of Six2 expression; ectopic Six2 expression is
also detected close to the developing otic vesicle (white arrow). (C,F) E12.5
embryos. In the mutant, Six2 signal is increased around the otic
vesicle (white arrow). (G,H) Expression of Sox9 in E12.5 wild-type
(G) and mutant (H) arches marking the position of the cartilaginous
condensations. Note the duplicated pattern in the mutant and its position
relative to the first branchial cleft (asterisk). (I,L) Sox9 (I) and
Six2 (L) probes were hybridized to adjacent sections of E11.5
branchial arches of the Hoxa2 mutant. Arrows indicate the expression
domains of Sox9 and Six2 in the first arch and their
duplication in the second arch. I, first arch; II, second arch; mx: maxilla;
o: otic vesicle; asterisk: first branchial cleft.
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