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Fig. 4. Hoxa2 is sufficient to repress Six2 in the facial mesenchyme. (A,B) In-situ hybridization with Six2 probe, in E10.5 wild-type embryo (A) and in E10.5 Msx2-Hoxa2 transgenic embryo (B). Six2 expression is downregulated in the maxilla (black arrow) and periocular mesenchyme (white arrow) of Msx2-Hoxa2 embryos. The corresponding embryo halves hybridized with the Hoxa2 probe are shown in the insets.





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