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Fig. 8. mol-/- embryos exhibit cranial motoneurone induction
and patterning defects. Lateral (A,B) and dorsal (C-J) views of wild-type (WT)
and mol-/- embryos labelled with various antibodies and
RNA probes (indicated bottom right) to reveal cranial motoneurones and their
axons. The unlabelled arrow in F shows a few Vp neurones in the
mol-/- embryo. Arrows in G and H show the trochlear
decussation in wild type (G) and its absence in mol-/- (H)
embryos. The arrow in J indicates foxa1 expression retained between
the two bilateral Va nuclei of the mol-/- mutant. III,
oculomotor nucleus; IV, trochlear motor nucleus; Va and Vp, anterior and
posterior components of the trigeminal motor nucleus; VII, facial motor
nucleus; X, vagal nucleus cb, cerebellum; pc, posterior commissure; R,
rhombomere.