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Fig. 9. Sequential segregation of lineages from founder cells in the DM sheet.
Schematic representation of the stage-dependent generation of restricted
progeny from the DM epithelium. DM precursors act as stem cells with
self-renewal ability in the epithelium. They express homogeneously both PAX3
and PAX7, divide with an orientation parallel to the apico-basal thickness of
the epithelium, and give rise to progeny that remain confined to the DM and
contribute to its mediolateral growth as long as the epithelium lasts. The DM
epithelium begins its dissociation into the ID, which reveals an aggregated
conformation. Most ID precursors either self-renew for one day and/or
segregate asymmetrically into ID and PMPs or ID and dermis (intermediate
restricted progeny). Finally, a significant proportion of ID cells generate
both PMP and dermis at E5, suggesting that these still keep a stem-like
character (see text for details).
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