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Fig. 2. Notch suppresses the activity of ArmadilloS10. Wing pouch region
of third larval instar wing discs showing the response of high (Senseless,
Sens) and low (Distalless, Dll) threshold targets of Wingless signalling to
normal or ectopic activity of Armadillo. (A-C) Wild type. (A) Distalless
expression; notice a slight elevation of the expression at the DV boundary.
The white line indicates the approximate domain of dpp expression.
(B) Senseless expression highlighting neural precursors that develop in
response to high levels of Wingless signalling
(Couso et al., 1993). (C)
Merged image of A and B. (D-F) Wing pouch of a disc expressing
ArmadilloS10 under the control of dppGAL4. (D) Distalless
expression is now elevated and expanded over the AP boundary. (E) Senseless
can be detected over a new domain along the AP boundary. (F) Merged image of
D, E. (G-I) Wing pouch of a disc expressing ArmadilloS10 and TNotch
under the control of dppGAL4. (G) The effects of
ArmadilloS10 on Distalless are suppressed by TNotch, a reduction of
wild-type levels is also observed. (H) The ectopic expression of Senseless
induced by ArmadilloS10 is suppressed by TNotch. Notice also the
reduction in the endogenous expression over the domain of TNotch expression.
(I) Merged image of G and H.
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