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Fig. 6. TNotch can suppress Wingless signalling induced by the loss of function of
GSK3ß/Shaggy. (A-D) Wild-type wing disc harbouring clones of cells mutant
for shaggy. (A,B) Loss of shaggy function (black in A,C)
leads to ectopic expression of the high threshold target of Wingless
signalling Senseless (B) and ectopic elevation of Armadillo (D). (E-H) Wing
discs expressing TNotch under the control of dppGal4 and containing
clones of cells lacking shaggy. TNotch reduces the ectopic expression
of Senseless (F) and the elevation of Armadillo (G). H is a merged colour
image of E-G. The effect on Senseless is fully penetrant but that on Armadillo
can be variable (A.M.A., unpublished data). Anterior is to the left and
posterior to the right.
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