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Fig. 8. Modulation of Wnt signalling by Notch in Drosophila (see text for
details of interactions). In the steady state, Armadillo exists in a number of
molecularly distinct pools which appear to be in equilibrium. Armadillo
associates readily with cadherin. Also it, associates with a complex, which
includes Axin and APC, leading to its phosphorylation on the N terminus by
GSK3ß (Shaggy) and the delivery of the phosphorylated form to the
proteasome, where it is degraded. In addition, Axin can prevent the formation
of its active complex with TCF in a GSK3ß-independent manner. Our results
indicate that Notch modulates the activity and amounts of hypophosphorylated
Armadillo either by targeting the GSK3ß-independent activity of Axin or
via an independent mechanism. The net effect of the inactivation of Notch and
the Axin-based complex results in an efficient accumulation of Armadillo in
the nucleus and its interaction with TCF.
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