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Fig. 1. Organization of the dorsal horn circuitry and identification of two waves
of neuronal migration in the dorsal spinal cord by BrdU labeling. (A)
Schematic diagram of the spinal cord circuitry. The dorsal horn can be divided
into several laminae. Laminae I-II (green) consist of small neurons in the
superficial dorsal horn, whereas laminae III-V (red) contain large neurons in
the deep dorsal horn. Proprioceptive afferents (light pink) innervate the
motoneurons in the ventral horn via a medial entry route. In the dorsal horn,
while mechanoreceptive afferents (red) project to laminae III-IV, nociceptive
afferents (green) project mainly to laminae I-II. (B,C) Distribution of E10.5
BrdU-labeled cells in E12.5 (B) and E13.5 (C) dorsal horns. There are no
BrdU-labeled cells in the superficial layer of E13.5 dorsal horns (arrow in
C). (D) Quantitative comparisons of E10.5 BrdU-labeled cells between the
dorsal and ventral horn at E11.5, E12.5 and E13.5. The percentages of
BrdU-labeled cells in the dorsal half of the spinal cord (black bar) decreases
(79.5%, 62.7% and 9.4%) progressively, while those of the labeled cells in the
ventral half (white bar) increases accordingly. (E) E11.5 BrdU-labeled cells
in E13.5 spinal cord. (F) E12.5 BrdU-labeled cells in E14.5 spinal cord. Scale
bars: 100 µm in B-D,F.
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