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Fig. 3. Epithelial integrity of the TE is not maintained in Cdx2 mutant embryos. (A) Immunolocalization of ZO-1{alpha}+ in Cdx2+/– early blastocyst. (B) ZO-1{alpha} + in Cdx2-/- early blastocyst. (C) Immunolocalization of E-cadherin in wild type embryo shown in A. (D) E-cadherin in Cdx2-/- embryo shown in B. (E) ZO-1{alpha} + in Cdx2+/– late blastocyst. (F) ZO-1{alpha} + in extreme example of a Cdx2-/- late blastocyst. (G) E-cadherin in Cdx2+/– late blastocyst. (H) E-cadherin in typical Cdx2-/- late blastocyst. (A-F) Projections of multiple optical sections. (G,H) Single sections.





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