spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online April 13, 2005

Development 132, 903e (2005)
© The Company of Biologists Limited
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in Development
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content

In this issue

Dronc drives cell death in flies


Apoptosis is a crucial feature of metazoan development that helps to shape tissues throughout the body. In Drosophila, Dronc - a caspase thought to act near the start of the apoptosis pathway - has been implicated in developmental apoptosis but its exact role has remained unclear. Now, on p. 2125, Xu and co-workers have used a novel mutagenesis screen in Drosophila to generate and characterise several loss-of-function dronc mutants. Their analysis of dronc-null embryos - and of the wings and eyes of the few dronc mutant flies that survived to adulthood - shows that dronc is essential for most apoptotic death during Drosophila development. The researchers' findings also reveal that dronc acts genetically downstream of the apoptosis inhibitor diap1 but, importantly, they note that some cells still undergo apoptosis in dronc mutants. Future studies should elucidate the nature of the dronc-independent pathway responsible for these deaths.


Related articles in Development:

The CARD-carrying caspase Dronc is essential for most, but not all, developmental cell death in Drosophila
Dongbin Xu, Ying Li, Michael Arcaro, Melinda Lackey, and Andreas Bergmann
Development 2005 132: 2125-2134. [Abstract] [Full Text]  




This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in Development
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content