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Fig. 1. Lvp38 inhibition specifically blocks oral specification. (A) Alignment of Lvp38 (Lv) and human p38 (Hs). Residues that are identical or 90% similar (Corpet, 1988) are indicated in red. The phosphorylation motif TGY is labeled blue. Specific SB-interacting residues are labeled green, and non-specific SB-interacting structural elements are labeled gray. (B) Brightfield images are shown of control (B1), KI p38-expressing (1.4 pg/pl, B2) and SB-treated (20 µM, B3) embryos. (C) Control (top) and SB-treated (bottom) embryos shown at early gastrula (C1,C2), late gastrula (C3,C4) and pluteus stages (C5,C6). (D) D1 and D2 show immunostaining of PMCs with 1d5 at the mesenchyme blastula stage in control (D1) and SB-treated (D2) embryos. Images are full projections of confocal z-series. (D3,D4) Whole-mount in situ analysis of FoxA in control (D3, late gastrula) and SB-treated (D4, pluteus stage) embryos, shown in lateral views. (E) Control (E1), KI p38-expressing (E2) and SB-treated (E3) embryos were immunolabeled with the aboral marker 1c10 at pluteus stage. Full projections are shown.





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