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Fig. 2. Hh processing and activity in Drosophila wing imaginal
discs. (A) A schematic of Hh processing, which involves the removal
of the C-terminal half at G257 and the concomitant addition of cholesterol.
Palmitic acid is also added onto a N-terminal cysteine, in a reaction
catalyzed by Sightless, a membrane bound O-acyltransferase. (B)
HhNpalm consists of only the N-terminal part of Hh, which is not
cholesterol modified, as the catalytic C-terminal part is missing. The
addition of palmitic acid to this form is thought to be unaffected. (C)
HhC85Scholes contains a point mutation, replacing cysteine 85 with
serine. This form of Hh carries cholesterol but no palmitoyl adduct.
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