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Fig. 8. Loss of dig-1 causes defects in basement membrane
structure. Transverse section of a region in the head of an adult worm is
shown. P, pharynx; D, sensory neuron dendrites; M, muscle. Scale bar: 1 µm.
In wild-type animals, thin and `fuzzy' basement membrane material is deposited
on tissues that neighbor the axons, such as pharynx and muscle (white arrows).
In dig-1 mutants, basement membrane is detached and forms
disorganized stacks and whorls (white arrowheads). It is unclear if the whorls
of basement membrane material derive from muscle or hypodermis, but they
appear thinner and simpler than the pharyngeal basement membrane material.
dig-1(ky188) (n=6), dig-1(nu345) (n=2) and
dig-1(n1321) (n=1) show similar defects, which are never see
in N2 wild-type animals (n=5).
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