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Figure 2


Fig. 2. Molecularly distinct DA cell populations in the mouse ventral midbrain. (A, part a) An E12.5 mouse embryo. The black line marks the plane of section shown in the image to the right. (A, part b) An enlarged view of the ventral midbrain (square box in A, part a), illustrating the position occupied by mitotic progenitors, immature and mature postmitotic neurons of the mDA lineage. (B) The sequential timing of transcription factor activation in mDA progenitors. The curved arrow indicates cycling cells. (C) The timing of expression of transcription factors in mDA progenitors (not in subsequent steps of the lineage) are shown. Dotted lines indicate that the precise timing of expression shutdown has not been determined. Images in A, part a, and A, part b are courtesy of the Ang Laboratory.





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