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Figure 4


Fig. 4. Ngn2 is required for Th+ DA neuron generation, and Mash1 partially compensates for Ngn2 function in the ventral midbrain. Coronal sections showing the expression of Th in DA neurons in the ventral midbrain of (A) wild-type and (B-D) mutant E14.5 mouse embryos. A severe reduction in Th+ DA neuron number in (B) Ngn2-/- and in (C) Ngn2-/-;Mash1-/- mutant embryos is observed, which is not evident in (D) Mash1-/- embryos, which have wild-type numbers of Th+ DA neurons. (E) Partial rescue in the number of Th+ DA neurons in Ngn2KIMash1/KIMash1 (Ngn2KIM1/KIM1) embryos. Modified, with permission, from Kele et al. (Kele et al., 2006).





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