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Figure 6


Fig. 6. Inhibition of CNC migration by ß1 integrin function blocking antibody. The motile behavior of CNC cells treated with ß1 integrin function blocking antibody was monitored by time lapse imaging and motion analysis, with images captured every 10 minutes. The change in directionality and speed of cell locomotion was compared with untreated cells and plotted as percent change in directionality (A) or speed (B). The wild-type CNCs show a reduction in speed and directionality within 1 hour of antibody treatment. The Cx43{alpha}1 KO and CMV43 CNCs showed a delayed response to the inhibitory effects of the antibody treatment. Error bars indicate s.e.m. *1 P<0.05, *2 P<0.01, *3 P<0.001 when compared with pre-antibody treatment; *4 P<0.05, *5 P<0.01 when compared with 1 hour of antibody treatment; *6 P<0.05 when compared with 2 hours of antibody treatment. Number of cells analyzed: 16, wild type; 19, Cx43{alpha}1KO; 20, CMV43.





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