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First published online September 12, 2006

Development 133, 1902e (2006)
© The Company of Biologists Limited
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In this issue

Tsukushi double action in primitive streak induction


Figure 1

The induction of the primitive streak, which defines the axes of the embryo, occurs during gastrulation. In chick embryos, its induction and that of Hensen's node (a thickening of the anterior primitive streak that acts as an organizer) requires VG1 (a TGFß superfamily member) signals, WNT signals and BMP antagonists. On p. 3777, Ohta and co-workers report that Tsukushi (TSK) - originally identified as a BMP antagonist - cooperates with VG1 to promote the formation of the primitive streak and Hensen's node. They show that alternative splicing of TSK mRNA produces TSKA and TSKB; both proteins interact with VG1, but TSKA is the stronger BMP antagonist. TSKA expression is highest in Hensen's node (a source of anti-BMP signals), they report, whereas TSKB accumulates in the middle of the primitive streak (where VG1 is expressed) and is required for the induction of Hensen's node. The researchers conclude that the TSK isoforms are crucial modulators of the VG1 and BMP branches of TGFß signalling during gastrulation.


Related articles in Development:

Tsukushi cooperates with VG1 to induce primitive streak and Hensen's node formation in the chick embryo
Kunimasa Ohta, Sei Kuriyama, Tatsuya Okafuji, Ryu Gejima, Shin-ichi Ohnuma, and Hideaki Tanaka
Development 2006 133: 3777-3786. [Abstract] [Full Text]  




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