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First published online January 25, 2006

Development 133, 403e (2006)
© The Company of Biologists Limited
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In this issue

Hox gets surprisingly direct


Figure 1

Almost all animal species use Hox genes to determine developmental cell fate and morphology, and on p. 641, Cameron and co-workers investigate how Hox genes regulate programmed cell death. The C. elegans Hox gene mab-5 is required for the programmed death of two related cells in the posterior ventral nerve cord: P11.aaap and P12.aaap. Programmed cell death in C. elegans requires the BH3-domain gene egl-1, and the researchers found that, in the P11.aaap cell, MAB-5 (together with its cofactor CEH-20) activates egl-1 transcription by directly interacting with a consensus binding site in the egl-1 regulatory sequence (although, remarkably, the death of P12.aaap is determined in a different fashion). This is the first time that a cell biological effector gene - rather than a transcription factor - has been found to be directly regulated by Hox proteins in C. elegans. Together with similar findings from Drosophila, this indicates that non-homeotic targets of Hox proteins, including targets that control programmed cell death, might be more common than previously thought.


Related articles in Development:

Direct regulation of egl-1 and of programmed cell death by the Hox protein MAB-5 and by CEH-20, a C. elegans homolog of Pbx1
Huarui Liu, Tamara J. Strauss, Malia B. Potts, and Scott Cameron
Development 2006 133: 641-650. [Abstract] [Full Text]  




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