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Figure 8


Fig. 8. Clonal inactivation of Notch1 in postnatal RPCs. P0 or P3 Notch1 flox/flox mice retinae were infected in vivo with a replication incompetent retrovirus encoding alkaline phosphatase without or with cre recombinase (pLIA versus pLIA-CRE). (A) Representative clones from a LIA infection including one single rod clone and one bipolar clone. (B,C) Quantitation of cell types resulting from LIA or LIA-CRE infections on Notch1 flox/flox retinae at P0 (B) and P3 (C). Three independent retinae totaling 400-800 clones were analyzed for each timepoint and type of virus. Change in cell types in the LIA-CRE-infected compared with control (LIA-infected retinae) is statistically significant (*P<0.05, **P<0.01, two-tailed t-test assuming equal variances).





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