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First published online February 24, 2006

Development 133, 602e (2006)
© The Company of Biologists Limited
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In this issue

BRICKing up actin nucleation


Figure 1

The nucleation of actin filaments by the Arp2/3 complex, which can be activated by Scar/WAVE, is essential for many eukaryotic cellular processes, including cell migration in animals and plant epidermal cell morphogenesis. Genetic studies in Arabidopsis have revealed the functions of several conserved components of a Scar/WAVE regulatory complex during trichome (epidermal hair) formation. Now, Djakovic and colleagues report that BRICK1 (BRK1), the plant homolog of the mammalian Scar/WAVE complex component HSPC300, regulates epidermal cell shape in Arabidopsis in concert with SCAR and the ARP2/3 complex (see p. 1091). The researchers show that mutations in BRK1 cause similar morphological defects in trichomes and other epidermal cells to those caused by mutations that disrupt the ARP2/3 complex. Epidermal defects in plants containing mutations in both BRK1 and ARP2/3 components are no more extreme than those in single mutants, indicating that BRK1 acts within the ARP2/3 pathway. Finally, the researchers show that BRK1 protects SCAR1 protein from degradation, which may explain how BRK1 controls ARP2/3 complex activity.


Related articles in Development:

BRICK1/HSPC300 functions with SCAR and the ARP2/3 complex to regulate epidermal cell shape in Arabidopsis
Stevan Djakovic, Julia Dyachok, Michael Burke, Mary J. Frank, and Laurie G. Smith
Development 2006 133: 1091-1100. [Abstract] [Full Text]  




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