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Figure 5


Fig. 5. NICD1-activated hearts in a Hesr1-null background at E10.5. Hesr1-null mice do not show any detectable defects (A,C,E) and NICD1-activation in Hesr1-null induced heart defects (B,D) is similar to NICD-activation in Hesr1-positive mice. Hematoxylin and Eosin analysis also revealed impaired trabeculation, the appearance of cell masses in the AV cushion (arrowhead) and a right-shifted interventricular septum (arrow). However, the AV myocardium is recovered (brackets) (F). Abbreviations: LA, left atrium; RA, right atrium; LV, left ventricle; RA, right ventricle. Scale bar: 1 mm in B; 500 µm in D; 200 µm in F.





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