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Fig. 6. Potential roles of 
6ß1-laminin interactions during early
myotome formation in the mouse. (A) (1) Our results strongly
suggest that 6ß1-laminin interactions repress myogenesis in the
dermomyotome (yellow cells). This repression is lifted when
6ß1-laminin binding is broken, an event that normally occurs at
the epaxial lip (green cells). (2) 6ß1 expression is maintained on
early Myf5-expressing MPCs and our results demonstrate that 6ß1 on
early MPCs is required for the assembly of the first myotomal laminin matrix.
(B) (3) At slightly later stages, Myf5-positive MPCs continue to
colonise the myotomal space and their guidance into this space is also
dependent on 6ß1-laminin interactions. The majority of these cells
stay in close contact with laminin and do not proceed further in their
differentiation programme until they reach the central area of the myotome.
(4) This central area near the myotome-sclerotome interface is the area where
the laminin matrix is discontinuous and cells expressing Myf5 and myogenin are
found. (5) With the addition of younger cells at the myotome-sclerotome
interface, elongating myocytes lose contact with laminin except at their
caudal and cranial extremities. This laminin matrix may play a role in
supporting their elongation.
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