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First published online April 12, 2006

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LEAFY feeds forwards

The meristem identity regulator LEAFY (LFY) is crucial for the switch from vegetative growth to flower development in plants. Two downstream targets of LFY are known in this pathway - APETELA1 and CAULIFLOWER (CAL) - but the rest of the regulatory cascade is poorly understood. Doris Wagner recently identified five new LFY targets; now her group has found that one of these - LATE MERISTEM IDENTITY 1 (LMI1) - is a meristem identity regulator (p. 1673). lmi1 mutants enhance the phenotype of a weak lfy mutant, abolishing CAL induction; moreover, LMI1 binds to the CAL promoter, indicating that LMI1 activates CAL directly. This interaction between LFY, LMI1 and CAL resembles a transcriptional network motif called a feed-forward loop: LFY activates LMI1, then both activate CAL. The authors explain how this feed-forward loop might ensure that the switch to reproductive development does not respond to transient environmental changes. LMI1 also has LFY-independent roles in leaf development and in leaflet and bract suppression; the authors suggest possible targets of this LMI1 function.

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The LEAFY target LMI1 is a meristem identity regulator and acts together with LEAFY to regulate expression of CAULIFLOWER

Louis A. Saddic, Bärbel Huvermann, Staver Bezhani, Yanhui Su, Cara M. Winter, Chang Seob Kwon, Richard P. Collum, and Doris Wagner
Development 2006 133: 1673-1682. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?