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Fig. 5. Socs5-/- mice exhibit accelerated mammary gland
development. (A) Whole mounts and H&E-stained sections of
inguinal mammary glands from wild-type (WT) and Socs5-/-
mice at day 10 and 15 of gestation. (B) The number of alveoli was
scored in H&E images from wild-type and Socs5-/- mice
at 40x magnification and the area of the fat pad was measured using
ImageJ software. The number of alveoli/mm2 was calculated and the
percentage relative to wild-type was plotted. (C) Whole mounts and
H&E staining of inguinal mammary glands from NOD and NOD-SCID mice at day
5 of gestation. (D) The number of alveoli/mm2 from
wild-type, NOD, NOD-SCID, Stat6-/- and
IL-4-/-/IL-13-/- mice at day 5 of gestation
were plotted on a histogram for comparison.