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Fig. 1. Foxa1/2 are expressed in mDA progenitors and neurons and the timing of
inactivation of Foxa2 in Foxa2cko embryos.
(A-F,H-I''') Coronal adjacent sections of mouse embryos.
(A-F) Wild-type embryos. Co-localization of Foxa1/2 proteins with Lmx1a (A,B),
Nurr1 (C,D) and TH (E,F) demonstrate that Foxa1/2 are expressed in all mDA
cells in the ventral midbrain at E10.5 (A,B) and E12.5 (D-F). (G)
Schematic of the ventral part of the midbrain showing the expression of
markers in mDA cells at different developmental stages. For clarity,
expression of Foxa1/2 genes in other neuronal populations have been
omitted. (H-I''') Foxa2 protein detected by immunohistochemistry is
largely absent in ventral midbrain progenitors from E10.5 onwards. Scale bars:
75 µm.
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