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Figure 2


Fig. 2. Nkx2.2 is abnormally expressed ventrally, including in a small number of mDA progenitors, in Foxa1-/-;Foxa2cko but not Foxa2cko or Foxa1-/- embryos. (A-H') Coronal sections of mouse embryos. (A-D,A'-D') Lmx1a and Lmx1b are expressed normally in mDA progenitors of Foxa1-/-, Foxa2cko and Foxa1-/-;Foxa2cko mutants, as in control embryos. (E-H,E'-H') Nkx2.2 expression is expanded ventrally starting at E10.5. (I-L) A small number of Lmx1a+ Nkx2.2+ progenitors are observed in the ventral midbrain of Foxa1-/-;Foxa2cko but not Foxa1-/-, Foxa2cko and control embryos at E12.5. Scale bars: 75 µm.





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