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Figure 5


Fig. 5. Foxa1/2 are required for early and late differentiation of mDA neurons at E12.5. (A-L) Coronal sections of mouse embryos. (A-H) The number of immature Nurr1+ TH- (A-D) and En1+ TH- (E-H) neurons (green) increases at the expense of mature Nurr1+ TH+ (A-D) and En1+ TH+ mDA (E-H) neurons (yellow) in Foxa1/2 single-mutant embryos compared with the corresponding numbers in control embryos. The total number of neurons (immature plus mature mDA neurons) is reduced only in Foxa2cko;Foxa1-/- embryos when compared with the total number in control embryos. (I-L) TH+ AADC+ mature neuron number decreases in all mutant compared with control embryos (see quantification in Fig. 6). Scale bars: 75 µm.





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