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Fig. 7. Schematic summarising the sequential roles of Foxa1/2 during the three
different phases of development of mDA neurons from neural stem/progenitor
cells. During regional and neuronal specification, Foxa1/2 positively
regulates Ngn2 expression in mDA progenitors. Foxa1/2 is subsequently required
for Nurr1 and En1 expression in immature mDA neurons and for the expression of
aromatic L-amino acid decarboxylase (AADC) and tyrosine hydroxylase
(TH) in mature mDA neurons during early and late differentiation.
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