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Fig. 2. Gene expression map of the mouse anterior mesencephalon at E12.5.
Summary of the gene expression pattern and transmitter phenotype of each
domain (m1 to m7), obtained from the results shown in Figs
1,
5 and
7. In the m1 and m2 domains,
both GABAergic and glutamatergic neurons emerge. The hatched lines indicate
expression in subpopulations within each domain (i.e. expression of Helt and
Ngns, Lim1 and Brn3a, and of Gad1 and Vglut2, is mutually
exclusive). Note that the motoneurons of the oculomotor complex are not shown
in this map as their generation is completed at an earlier stage and the
motoneuron progenitor domain changes to the RN domain at E11.5 (data not
shown). RP, roof plate; VZ, ventricular zone; ML, mantle layer; Glut,
glutamatergic; DA, dopaminergic.
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