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Figure 3


Fig. 3. Reduced mitotic rates in hair follicles correlates with elevated expression of cytostatic and proapoptotic genes. (A) Microdissection of hair bulbs from embryo-deleted Notch1 (emN1) or anagen-deleted Notch1 (anN1)/wild-type (WT) follicles (grouped for this image because they have the same morphology). (B) Quantitative reverse transcriptase (qRT)-PCR of G1 cyclins, cyclin kinase inhibitors (CKIs; Cdkn1a, Cdkn2b and Cdkn1c), gasdermin 1 and Scotin using total RNA isolated from the microdissected samples shown in A. Error bars represent s.e.m. Scale bars: (A, left) 100 µm; (A, right) 200 µm.





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