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Fig. 5. A PCP-specific mutation in dsh does not affect the orientation
of cell divisions. In the same genetic background, wing hairs appear
dishevelled, indicating a PCP defect (A). Nevertheless, denticle
orientation appears normal in first instar larvae (B).
(C,D) Orientation of cell divisions in dsh-deficient
embryos during germband extension (GBE). Data for five embryos are shown with
average and standard error. For each embryo, 50 and 100 (randomly chosen)
divisions were counted for the fast (C) and slow (D) phases, respectively.
Longitudinal divisions are predominant during the fast phase of GBE. As in
wild-type embryos, a majority of fast-phase mitoses are oriented
longitudinally in dsh embryos. For each embryo, we calculated an
index of longitudinal bias as the absolute slope of the line relating the
angle of division to the proportion of cells dividing along that angle
(obtained from linear regression). We then compared the value of this index
for five dsh and five wild-type embryos and found no statistically
significant difference between the two groups (t-test,
P>0.05). We conclude, therefore, that the orientation of cell
divisions is unaffected in dsh mutant embryos.
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