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Figure 5


Fig. 5. The genetic locus of vmc encodes the zebrafish orthologue of plxna3. (A) Genetic map of the vmc locus. The vmc locus was genetically mapped between the SSLP markers fj56g03 (2.1 cM) and z15045 (1.4 cM) on chromosome 8. (B) Location of the missense amino acid substitutions in the three vmc mutant alleles in the zebrafish orthologue of plxna3. Mutations were located within the Sema domain (vmcrw260, E169D), in the IPT Plexin repeat 3 domain (vmcrw314, C1090S) and in the SP domain (vmcrw413, W1746R) of Plxna3. In addition, one allele (vmcrw260) carried a stop codon within the Sema domain.





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