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Figure 6


Fig. 6. Perfusion coefficients in wild-type and Mlc2a-/- mouse embryos. FRAP was used to measure perfusion coefficients within the early embryonic blood vessels in Mlc2a-/- and wild-type embryos at the 8- to 9-somite stage. Each measurement is plotted and three measurements were made from each embryo. The total number of embryos analyzed is indicated for each genotype. For reproducibility, measurements were always taken on the arterial side of the yolk sac near the caudal end of the embryo. Perfusion coefficient ranges were significantly lower in mutant than in wild-type embryos. In wild-type embryos, some perfusion coefficients were too fast to measure using FRAP (asterisk and arrow). By contrast, perfusion coefficients could always be measured in mutant embryos. Perfusion coefficients up to 3835 µm2/second were found in wild-type embryos, whereas the maximum perfusion rate seen in Mlc2a mutant embryos was 1045 µm2/second.





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