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Figure 8


Fig. 8. Model for FGF3 function in otic morphogenesis initiation. Oblique view of the developing hindbrain and otic vesicle during initiation of otic morphogenesis. The model integrates present data with those published previously. Otic vesicle molecular patterning and morphogenesis are initiated by WNT signals provided redundantly by roofplate-expressed Wnt3a and Wnt1 (dark blue). This signal induces otic Gbx2, which in turn induces Wnt2 and Dlx5 at a minimum, and is required for dorsal outgrowth of the EDS anlage. Fgf3, induced in r5-6 by Hoxa1 and Mafb [Mafb (Kr)], serves to maintain otic Gbx2 and its downstream genes, but has no direct effect on ventral otic genes (Pax2 and Otx2). In addition, Fgf3 prevents medial expansion of otic Hmx3 and ventral expansion of hindbrain Wnt3a. The role of sonic hedgehog (SHH) in ventral otic patterning via induction of Pax2 and Otx2 is illustrated, but was not addressed here.





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