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Fig. 5. Model of neuronal subtype specification in the retina by combinations of
HD and bHLH proteins. Different combinations of bHLH proteins (purple) and
HD proteins (red) are expressed by the different classes of neurons and glia
in the retina. From mouse mutant analyses and from coexpression of HD proteins
and bHLH proteins in mouse retinal explants, Hatakeyama and Kageyama have
proposed that the combinatorial activity of different HD and bHLH proteins
determines the fate of retinal cells. See text and Hatakeyama and Kageyama
(Hatakeyama and Kageyama,
2004) for details. NeuroD (Neurod1).