spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online November 9, 2007

Development 134, 2305e (2007)
© The Company of Biologists Limited
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in Development
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content

In this issue

GSCs and the Argonautes


Figure 1

Germline stem cells (GSCs) in the Drosophila ovary are an excellent model system in which to study the mechanisms that regulate stem cell maintenance and differentiation. Now, on p. 4265, Yang and co-workers report that Argonaute 1 (AGO1), a protein that is involved in small-RNA-mediated gene regulation, controls the fate of Drosophila GSCs. Piwi, another Argonaute protein, helps to maintain GSCs by silencing bag of marbles (bam), a gene that is required for GSC differentiation, but do other Argonaute proteins play similar roles? The researchers report that the overexpression of Ago1 leads to GSC overproliferation, whereas its loss causes a reduction in GSC numbers. This result, together with an analysis of the fate of germline clones that lack a functional Ago1 gene, suggests that an AGO1-dependent miRNA pathway probably plays an instructive role in repressing GSC differentiation. Finally, the researchers show that some GSCs partly differentiate in Ago1 bam double mutants, which suggests that AGO1 (unlike Piwi) might regulate GSC fate in a bam-independent manner.


Related articles in Development:

Argonaute 1 regulates the fate of germline stem cells in Drosophila
Lele Yang, Dongsheng Chen, Ranhui Duan, Laixin Xia, Jun Wang, Abrar Qurashi, Peng Jin, and Dahua Chen
Development 2007 134: 4265-4272. [Abstract] [Full Text]  




This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in Development
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content